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n. - A small hard painless nodule at the site of entry of a pathogen (as syphilis).

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Usage examples (34)
  • The first stage of infection during which an open sore called a chancre develops.
  • The chancre is a painless round nodule of thickened tissue, usually with a smooth appearance.
  • The disease is already systemic, or constitutional, and the chancre is the local expression of a constitutional disease.
  • · The first sign is usually a sore, called a chancre.
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Tutoring comment
  • "Cancer" is a malignant growth in the body or a wicked, spreading action or idea, a "canker" is a sore in the mouth, while a "chancre" is an ulcer caused by venereal disease.
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