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n. - A battle (333 BC) in which Alexander the Great defeated the Persians under Darius III.

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Usage examples (34)
  • No, Xodar, your Issus is a mortal old woman.
  • Issus; (c) battle of Arbela; and (d) death of Alexander.
  • Issus of Cilicia, now a port-village on the Gulf of Scanderoon.
  • After Issus, all of Phoenicia except Tyre submitted to Alexander.
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