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n. - A drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia.

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Usage examples (6)
  • The result was azathioprine (1957) which replaced mercaptopurine as an inhibitor of the immune response.
  • However, studies with a 6-mercaptopurine-resistant strain of L. casei revealed the 6-MP was unable to utilize hypoxanthine for growth (29).
  • Six weeks later, he gave the boy four courses of high-dose methotrexate, daily mercaptopurine, and four triple-drug treatments into the spinal fluid.
  • The liposomal ld50 of mercaptopurine was compared to fold 480 mg/kg in the and 425 mg/kg in the rat.
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