WordNet sense 1 (free from involvement or entanglement):

disembroil, disinvolve

WordNet sense 2 (release from entanglement of difficulty):

disencumber, extricate, untangle

WordNet sense 3 (separate the tangles of):

unwind

WordNet sense 4 (extricate from entanglement):

unsnarl, straighten out

WordNet sense 5 (smoothen and neaten with or as with a comb):

comb, comb out