WordNet sense 1 (suffering severe physical strain or distress):

stressed

WordNet sense 2 (facing or experiencing financial trouble or difficulty):

hard-pressed, hard put

WordNet sense 3 (afflicted with or marked by anxious uneasiness or trouble or grief):

disturbed, upset, worried, disquieted, upset

WordNet sense 4 (characterized by or indicative of distress or affliction or danger or need):

troubled

WordNet sense 5 (generalized feeling of distress):

unhappy, dysphoric