WordNet sense 1 (afflicted with or marked by anxious uneasiness or trouble or grief):

distressed, upset, worried, disquieted, upset

WordNet sense 2 (characterized by or indicative of distress or affliction or danger or need):

troubled

WordNet sense 3 (affected with madness or insanity):

crazy, demented, distracted, mad, sick, unbalanced, unhinged, brainsick

WordNet sense 4 (afflicted with or characteristic of mental derangement):

insane

WordNet sense 5 (having the arrangement disturbed; not in order):

disarranged

WordNet sense 6 (emotionally unstable and having difficulty coping with personal relationships):

maladjusted

WordNet sense 7 (affected with emotional disorder):

neurotic, psychoneurotic