WordNet sense 1 (English physician who first described Down's syndrome (1828-1896)):

John L. H. Down

WordNet sense 2 (fine soft dense hair (as the fine short hair of cattle or deer or the wool of sheep or the undercoat of certain dogs)):

pile

WordNet sense 3 (on or toward a surface regarded as a base):

downward

WordNet sense 4 (directed downward):

downcast

WordNet sense 5 (becoming lower or less in degree or value):

falling

WordNet sense 6 (coming down or downward):

descending

WordNet sense 7 (not allowed to continue to bat or run):

out, retired

WordNet sense 8 (shoot at and force to come down):

land

WordNet sense 9 (soft fine feathers):

down feather

WordNet sense 10 (understood perfectly):

mastered

WordNet sense 11 (being complete of its kind and without defect or blemish):

perfect, perfect

WordNet sense 12 (lower than previously):

depressed

WordNet sense 13 (less than normal in degree or intensity or amount):

low

WordNet sense 14 (below the surround or below the normal position):

lowered

WordNet sense 15 (cause to come or go down):

cut down, push down, pull down

WordNet sense 16 (drink down entirely):

kill, pop, toss off, belt down, bolt down, drink down, pour down

WordNet sense 17 (eat immoderately):

consume, devour, go through

WordNet sense 18 (not operating):

inoperative

WordNet sense 19 (low in spirits):

blue, dispirited, downhearted, low-spirited, down in the mouth

WordNet sense 20 (affected or marked by low spirits):

dejected

WordNet sense 21 (improve or perfect by pruning or polishing):

fine-tune, polish, refine, polish

WordNet sense 22 (spatially or metaphorically from a higher to a lower level or position):

downwards, downwardly