WordNet sense 1 (a phenomenon that follows and is caused by some previous phenomenon):

consequence, event, issue, result, upshot, outcome

WordNet sense 2 (the central meaning or theme of a speech or literary work):

burden, core, essence, gist

WordNet sense 3 ((of a law) having legal validity):

force

WordNet sense 4 (an outward appearance):

impression

WordNet sense 5 (produce):

effectuate, set up