WordNet sense 1 ((Roman Catholic Church) an Italian and the Roman Catholic monk who founded the Franciscan order of friars (1181-1226)):

Francis of Assisi, Giovanni di Bernardone, Saint Francis of Assisi, St. Francis, St. Francis of Assisi

WordNet sense 2 (a tributary of the Mississippi River that rises in Missouri and flows southeastward through Arkansas):

Saint Francis River, St. Francis River