WordNet sense 1 (drained of energy or effectiveness; extremely tired; completely exhausted):

dog-tired, washed-out, worn-out, fagged, fatigued, played out

WordNet sense 2 (emptied or exhausted of (as by drawing off e.g. water or other liquid)):

drained

WordNet sense 3 (having all been spent):

gone, spent

WordNet sense 4 (emptied by being pumped out or having a vacuum created):

evacuated

WordNet sense 5 (having resources completely depleted):

depleted