WordNet sense 1 (inflammation of the laminated tissue that attaches the hoof to the foot of a horse):

laminitis

WordNet sense 2 (a person who founds or establishes some institution):

beginner, father, Founding Father

WordNet sense 3 (fail utterly; collapse):

flop, fall through, fall flat

WordNet sense 4 (break down, literally or metaphorically):

break, collapse, give, cave in, fall in, give way