WordNet sense 1 (the appendage to an object that is designed to be held in order to use or move it):

grip, hold, handgrip

WordNet sense 2 (interact in a certain way):

treat, do by

WordNet sense 3 (be in charge of, act on, or dispose of):

care, deal, manage

WordNet sense 4 (handle effectively):

wield

WordNet sense 5 (touch, lift, or hold with the hands):

palm

WordNet sense 6 (deal with verbally or in some form of artistic expression):

address, cover, plow, address