WordNet sense 1 (hinder or prevent the progress or accomplishment of):

block, blockade, embarrass, obstruct, stymie, stymy

WordNet sense 2 (be a hindrance or obstacle to):

impede

WordNet sense 3 (put at a disadvantage):

hamper, handicap

WordNet sense 4 (located at or near the back of an animal):

back, hind

WordNet sense 5 (at or near the hind end in quadrupeds or toward the spine in primates):

posterior