WordNet sense 1 ((used of physical stimuli) serving to stimulate or excite):

irritative

WordNet sense 2 (capable of arousing or accelerating physiological or psychological activity or response by a chemical agent):

stimulative

WordNet sense 3 (causing physical discomfort):

painful

WordNet sense 4 (causing irritation or annoyance):

annoying, bothersome, galling, nettlesome, pesky, pestiferous, vexatious, pestering, plaguey, plaguy, teasing, vexing

WordNet sense 5 (not to your liking):

disagreeable