WordNet sense 1 (a state of difficulty that needs to be resolved):

problem, job

WordNet sense 2 (a book in the Old Testament containing Job's pleas to God about his afflictions and God's reply):

Book of Job

WordNet sense 3 (arranged for contracted work to be done by others):

subcontract, farm out

WordNet sense 4 (invest at a risk):

speculate

WordNet sense 5 (a crime (especially a robbery)):

caper

WordNet sense 6 (a specific piece of work required to be done as a duty or for a specific fee):

chore, task

WordNet sense 7 (the principal activity in your life that you do to earn money):

business, line, occupation, line of work