WordNet sense 1 (characterized by malice):

hateful, mean

WordNet sense 2 (vile; despicable):

dirty, filthy, lousy

WordNet sense 3 (offensive or even (of persons) malicious):

awful

WordNet sense 4 (exasperatingly difficult to handle or circumvent):

tight

WordNet sense 5 (not easy; requiring great physical or mental effort to accomplish or comprehend or endure):

difficult, hard

WordNet sense 6 (characterized by obscenity):

foul, smutty

WordNet sense 7 (soiled or likely to soil with dirt or grime):

soiled