Synonyms for Nettlesome (same or very similar meaning)
WordNet sense 1 (easily irritated or annoyed):
cranky, fractious, irritable, peevish, pettish, petulant, scratchy, testy, peckish, techy, tetchy
WordNet sense 2 (having an irritable and unpleasant disposition):
ill-natured
WordNet sense 3 (causing irritation or annoyance):
annoying, bothersome, galling, irritating, pesky, pestiferous, vexatious, pestering, plaguey, plaguy, teasing, vexing
WordNet sense 4 (not to your liking):
disagreeable
From the ODE community, based on WordNet
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