WordNet sense 1 (direct or control; projects, businesses, etc.):

run

WordNet sense 2 (perform as expected when applied):

function, go, work

WordNet sense 3 (keep engaged):

engage, lock, mesh

WordNet sense 4 (handle and cause to function):

control

WordNet sense 5 (perform a movement in military or naval tactics in order to secure an advantage in attack or defense):

maneuver, manoeuver, manoeuvre

WordNet sense 6 (perform surgery on):

operate on