WordNet sense 1 (a symptom of some physical hurt or disorder):

hurting

WordNet sense 2 (a bothersome annoying person):

nuisance, pain in the neck

WordNet sense 3 (emotional distress; a fundamental feeling that people try to avoid):

painfulness

WordNet sense 4 (something or someone that causes trouble; a source of unhappiness):

annoyance, bother, infliction, botheration, pain in the ass

WordNet sense 5 (a somatic sensation of acute discomfort):

painful sensation, pain sensation

WordNet sense 6 (cause emotional anguish or make miserable):

anguish, hurt

WordNet sense 7 (cause bodily suffering to and make sick or indisposed):

afflict, ail, trouble