WordNet sense 1 (causing misery or pain or distress):

afflictive

WordNet sense 2 (disagreeable to the senses, to the mind, or feelings ):

unpleasant

WordNet sense 3 (hurting):

raw, sensitive, sore, tender

WordNet sense 4 (keenly distressing to the mind or feelings):

poignant

WordNet sense 5 (producing or having a painfully hot sensation):

burning

WordNet sense 6 (causing a sharply painful or stinging sensation; used especially of cold):

biting

WordNet sense 7 (extremely painful):

agonizing, excruciating, harrowing, torturous

WordNet sense 8 (exceptionally bad or displeasing):

abominable, atrocious, awful, dreadful, terrible, unspeakable

WordNet sense 9 (causing physical discomfort):

irritating

WordNet sense 10 (providing or experiencing physical discomfort):

uncomfortable