WordNet sense 1 (not affording rest):

uneasy

WordNet sense 2 (unable to relax or be still):

antsy, fidgety, fretful, itchy

WordNet sense 3 (characterized by unrest or disorder):

unquiet

WordNet sense 4 (in motion):

moving

WordNet sense 5 (worried and uneasy):

unsatisfied, ungratified

WordNet sense 6 (showing or experiencing dissatisfaction or restless longing):

discontent, discontented