WordNet sense 1 (an irrecoverable state of devastation and destruction):

ruination

WordNet sense 2 (the process of becoming dilapidated):

dilapidation

WordNet sense 3 (failure that results in a loss of position or reputation):

downfall

WordNet sense 4 (reduce to bankruptcy):

bankrupt, break, smash

WordNet sense 5 (destroy completely; damage irreparably):

destroy

WordNet sense 6 (deprive of virginity):

deflower

WordNet sense 7 (destruction achieved by causing something to be wrecked or ruined):

ruining, wrecking, laying waste