Synonyms for Ruination (same or very similar meaning)
WordNet sense 1 (an irrecoverable state of devastation and destruction):
ruinWordNet sense 2 (failure that results in a loss of position or reputation):
downfallWordNet sense 3 (destruction achieved by causing something to be wrecked or ruined):
ruining, wrecking, laying wasteFrom the ODE community, based on WordNetadd/edit