WordNet sense 1 (shabby and untidy):

scruffy

WordNet sense 2 (affected by wear; damaged by long use):

worn

WordNet sense 3 (somewhat ill or prone to illness):

ailing, indisposed, peaked, poorly, sickly, unwell, peaked, under the weather

WordNet sense 4 (affected by an impairment of normal physical or mental function):

ill, sick

WordNet sense 5 (morally degraded):

seamy, sleazy, sordid, squalid

WordNet sense 6 (lacking respectability in character or behavior or appearance):

disreputable