WordNet sense 1 (someone who is incapacitated by a chronic illness or injury):

invalid, invalid

WordNet sense 2 (somewhat introverted):

introvertish

WordNet sense 3 (directed inward; marked by interest in yourself or concerned with inner feelings):

introversive, introvertive

WordNet sense 4 (confined usually by illness):

housebound, homebound

WordNet sense 5 (not free to move about):

confined