WordNet sense 1 (misery resulting from affliction):

woe

WordNet sense 2 (a state of acute pain):

agony, excruciation

WordNet sense 3 (psychological suffering):

distress, hurt

WordNet sense 4 (characterized by or indicative of distress or affliction or danger or need):

troubled

WordNet sense 5 (very unhappy; full of misery):

miserable, wretched

WordNet sense 6 (experiencing or marked by or causing sadness or sorrow or discontent):

unhappy