WordNet sense 1 (very sophisticated especially because of surfeit; versed in the ways of the world):

worldly

WordNet sense 2 (having or appealing to those having worldly knowledge and refinement and savoir-faire):

sophisticated

WordNet sense 3 (uninterested because of frequent exposure or indulgence):

bored

WordNet sense 4 (not having or showing interest):

uninterested

WordNet sense 5 (lacking in interest or care or feeling):

unconcerned