WordNet sense 1 (hoop that covers a wheel):

tyre

WordNet sense 2 (deplete):

exhaust, sap, run down, play out

WordNet sense 3 (cause to be bored):

bore

WordNet sense 4 (get tired of something or somebody):

fatigue, jade, pall, weary

WordNet sense 5 (exhaust or get tired through overuse or great strain or stress):

outwear, wear, fag out, tire out, wear upon, wear down, wear out