WordNet sense 1 (a strong feeling of anxiety):

worry

WordNet sense 2 (an angry disturbance):

bother, fuss, hassle

WordNet sense 3 (a source of difficulty):

problem

WordNet sense 4 (to cause inconvenience or discomfort to):

discommode, disoblige, incommode, inconvenience, put out

WordNet sense 5 (take the trouble to do something; concern oneself):

trouble oneself, inconvenience oneself

WordNet sense 6 (move deeply):

disturb, upset, upset

WordNet sense 7 (disturb in mind or make uneasy or cause to be worried or alarmed):

cark, disorder, disquiet, distract, perturb, unhinge

WordNet sense 8 (an effort that is inconvenient):

difficulty

WordNet sense 9 (cause bodily suffering to and make sick or indisposed):

afflict, ail, pain