WordNet sense 1 (full of trouble):

troublous

WordNet sense 2 (suffering severe physical strain or distress):

distressed

WordNet sense 3 (afflicted with or marked by anxious uneasiness or trouble or grief):

disturbed, upset, worried, upset

WordNet sense 4 (full of cares or anxiety):

careful

WordNet sense 5 (causing or fraught with or showing anxiety):

anxious, uneasy

WordNet sense 6 (troubled persistently especially with petty annoyances):

annoyed

WordNet sense 7 (characterized by unrest or disorder or insubordination):

disruptive, riotous, tumultuous, turbulent