WordNet sense 1 (excessively and uncomfortably conscious of your appearance or behavior):

self-conscious

WordNet sense 2 (caused to feel self-conscious and uncomfortable):

embarrassed

WordNet sense 3 (not at ease socially; unsure and constrained in manner):

awkward, uneasy

WordNet sense 4 (characterized by physical misery):

miserable, wretched

WordNet sense 5 (causing physical discomfort):

irritating