WordNet sense 1 (physical discomfort (as mild sickness or depression)):

malaise, unease

WordNet sense 2 (feelings of anxiety that make you tense and irritable):

disquietude, edginess, inquietude

WordNet sense 3 (embarrassment deriving from the feeling that others are critically aware of you):

self-consciousness, uncomfortableness

WordNet sense 4 (the trait of seeming ill at ease):

disquiet

WordNet sense 5 (inability to rest or relax or be still):

queasiness, restlessness