WordNet sense 1 (causing or fraught with or showing anxiety):

anxious, nervous, queasy

WordNet sense 2 (characterized by or indicative of distress or affliction or danger or need):

troubled

WordNet sense 3 (not affording rest):

restless

WordNet sense 4 (characterized by unrest or disorder):

unquiet

WordNet sense 5 (affording no ease or reassurance):

precarious, unstable

WordNet sense 6 (mentally upset over possible misfortune or danger etc):

apprehensive, worried

WordNet sense 7 (not at ease socially; unsure and constrained in manner):

awkward