WordNet sense 1 (causing or fraught with or showing anxiety):

anxious, nervous, queasy

WordNet sense 2 (characterized by or indicative of distress or affliction or danger or need):

troubled

WordNet sense 3 (not affording rest):

restless, uneasy

WordNet sense 4 (characterized by unrest or disorder or insubordination):

turbulent

WordNet sense 5 (unable to relax or be still):

antsy