WordNet sense 1 (an angry disturbance):

fuss, hassle, trouble

WordNet sense 2 (something or someone that causes trouble; a source of unhappiness):

annoyance, infliction, pain, botheration, pain in the ass, pain in the neck

WordNet sense 3 (to cause inconvenience or discomfort to):

discommode, disoblige, incommode, inconvenience, put out

WordNet sense 4 (take the trouble to do something; concern oneself):

trouble oneself, inconvenience oneself

WordNet sense 5 (cause annoyance in; disturb, especially by minor irritations):

annoy, chafe, devil, gravel, irritate, nark, nettle, rag, rile, vex, get at, get to