WordNet sense 1 (physically and mentally fatigued):

aweary

WordNet sense 2 (depleted of strength or energy):

tired

WordNet sense 3 (get tired of something or somebody):

fatigue, jade, pall, tire

WordNet sense 4 (exhaust or get tired through overuse or great strain or stress):

outwear, wear, fag out, tire out, wear upon, wear down, wear out