WordNet sense 1 (tormented or harassed by nightmares or unreasonable fears):

hagridden, hag-ridden

WordNet sense 2 (characterized by or indicative of distress or affliction or danger or need):

troubled

WordNet sense 3 (experiencing intense pain especially mental pain):

anguished, tortured

WordNet sense 4 (experiencing or marked by or expressing sorrow especially that associated with irreparable loss):

sorrowful