WordNet sense 1 (marked by spirited enjoyment):

yeasty, zestful, zesty

WordNet sense 2 (displaying animation, vigor, or liveliness):

spirited

WordNet sense 3 (informal or slang terms for mentally irregular):

balmy, batty, bonkers, buggy, cracked, crackers, daft, dotty, fruity, haywire, kooky, loco, loony, loopy, nuts, nutty, wacky, kookie, whacky, around the bend, bats, round the bend

WordNet sense 4 (afflicted with or characteristic of mental derangement):

insane