Synonyms for Aggravation (same or very similar meaning)
WordNet sense 1 (an exasperated feeling of annoyance):
exasperationWordNet sense 2 (unfriendly behavior that causes anger or resentment):
irritation, provocationWordNet sense 3 (action that makes a problem or a disease (or its symptoms) worse):
exacerbationFrom the ODE community, based on WordNetadd/edit