WordNet sense 1 (doomed to extinction):

sunk, undone, washed-up, done for

WordNet sense 2 (not successful; having failed or having an unfavorable outcome):

unsuccessful

WordNet sense 3 (spiritually or physically doomed or destroyed):

lost

WordNet sense 4 (spoiled or ruined or demolished):

destroyed

WordNet sense 5 (brought to ruin):

finished