WordNet sense 1 (everything that exists anywhere):

cosmos, existence, macrocosm, universe, world

WordNet sense 2 (the event that occurred at the beginning of something):

conception

WordNet sense 3 (the human act of creating):

creative activity

WordNet sense 4 (the act of starting something for the first time; introducing something new):

foundation, initiation, innovation, instauration, institution, introduction, origination, founding