WordNet sense 1 (any affliction that causes great suffering):

crown of thorns

WordNet sense 2 (a marking that consists of lines that cross each other):

crisscross, mark

WordNet sense 3 (to cover or extend over an area or time period):

span, sweep, traverse

WordNet sense 4 (hinder or prevent (the efforts, plans, or desires) of):

baffle, bilk, foil, frustrate, scotch, spoil, thwart

WordNet sense 5 (meet at a point):

intersect

WordNet sense 6 (travel across or pass over):

cover, track, cut across, get across, get over, pass over, cut through

WordNet sense 7 (extending or lying across; in a crosswise direction; at right angles to the long axis):

transverse, thwartwise, transversal

WordNet sense 8 (breed animals or plants using parents of different races and varieties):

crossbreed, hybridize, interbreed, hybridise

WordNet sense 9 (an organism that is the offspring of genetically dissimilar parents or stock; especially offspring produced by breeding plants or animals of different varieties or breeds or species):

hybrid

WordNet sense 10 (perversely irritable):

bad-tempered, crabbed, crabby, fussy, grouchy, grumpy, ill-tempered

WordNet sense 11 ((genetics) the act of mixing different species or varieties of animals or plants and thus to produce hybrids):

crossing, hybridization, crossbreeding, hybridisation, hybridizing, interbreeding