WordNet sense 1 (providing no shelter or sustenance):

bare, barren, bleak, stark

WordNet sense 2 (unfavorable to life or growth):

inhospitable

WordNet sense 3 (sad beyond comforting; incapable of being consoled):

disconsolate, unconsolable

WordNet sense 4 (leave someone who needs or counts on you; leave in the lurch):

abandon, desert, forsake, desert

WordNet sense 5 (reduce in population):

depopulate

WordNet sense 6 (devastate or ravage):

devastate, ravage, scourge, waste, lay waste to