The specific target of the immune response in rheumatoid arthritis is filaggrin.    From Wordnet, Princeton University. 

Later on, an approved gene name filaggrin-2 (gene symbol FLG2) was suggested by the HUGO / GDB Nomenclature Committee.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

"Our findings suggest that filaggrin is a robust biomarker for allergic conditions.".    From Wordnik.com.  [Medlogs - Recent stories] Reference

But not everyone who has filaggrin variations associated with eczema will get the skin condition.    From Wordnik.com.  [Science News / Features, Blog Entries, Column Entries, Issues, News Items and Book Reviews] Reference

As a vital component of healthy skin, filaggrin is also a precursor of natural moisturizing factors.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Some people with eczema have a defect in filaggrin, a protein that helps form the skin's protective barrier.    From Wordnik.com.  [Science News / Features, Blog Entries, Column Entries, Issues, News Items and Book Reviews] Reference

The link between atopic eczema and filaggrin gene mutations appeared to be particularly strong, the study found.    From Wordnik.com.  [Medlogs - Recent stories] Reference

They called for further research to investigate whether filaggrin can be used to identify people at high risk for allergic conditions.    From Wordnik.com.  [Medlogs - Recent stories] Reference

A purchase generic antabuse online titration tympanostomy hastening terazosin, a selective, once-a-day 1-blocker for the filaggrin of basic benign osteopenic hyperplasia.    From Wordnik.com.  [Wii-volution] Reference

Therefore, the spatial localisation of FLG2 in comparison with that of filaggrin was further analysed by immunofluorescent staining and laser scanning confocal microscopy.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

FLG2 gene encodes a histidine - and glutamine-rich protein of approximately 248 kDa, which shares common structural features with other SFTP members, in particular filaggrin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Recent genetic studies have shown that mutations within the gene encoding the SFTP filaggrin cause ichthyosis vulgaris and are major predisposing factors for atopic dermatitis.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The liberated filaggrin is an essential component of the SC that participates in the aggregation of keratin filaments into bundles and promote the flattened shape of dead-cell remnants.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

FLG2 mRNA expression displayed almost the same kinetics as that of filaggrin following Ca2+ stimulation, suggesting an important role in molecular regulation of epidermal terminal differentiation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In all those tested, the active cells increased and maintained moisture in the upper layers of the epidermis, while raised levels of filaggrin proteins helped to protect the skin from further damage.    From Wordnik.com.  [We Blog A Lot] Reference

To search for additional S100 fused-type proteins within the SFTP genes cluster, a BLAST search with the N-terminal 82 amino-acid sequence of filaggrin was performed and identified several putative gene loci.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We provide evidences that like filaggrin, FLG2 is initially expressed by upper granular cells, proteolytically processed and deposited in the stratum granulosum and stratum corneum (SC) layers of normal epidermis.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Restoring skin barrier function early in life in people with filaggrin defects might help prevent the development of allergic sensitization and stop the development and progression of allergic disorders, the researchers suggested.    From Wordnik.com.  [Medlogs - Recent stories] Reference

FLG2 and filaggrin may have overlapping and perhaps synergistic roles in the formation of the epidermal barrier, protecting the skin from environmental insults and the escape of moisture by offering precursors of natural moisturizing factors.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Involucrin and filaggrin, late markers of epidermal differentiation, were detected in the uppermost layers only. 12 weeks after grafting onto five immunodeficient mice, epidermis derived from K-hESCs had a structure consistent with that of mature human skin.    From Wordnik.com.  [Science Fiction in the News] Reference

"These findings provide strong supporting evidence that, at least in a subset of those with allergic problems, the filaggrin gene defect may be the fundamental predisposing factor not only for the development of eczema but also for initial sensitization and progression of allergic disease," the study authors wrote.    From Wordnik.com.  [Medlogs - Recent stories] Reference

By using these tandem repeats as queries in BLAST homolog searches against the human protein database, the most positive hit homologous to each A-type repeat was from repetitive domains of hornerin (50-77\% identity) whereas that homologous to each B-type repeat was from filaggrin units (28-39\% identity) (data not shown).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Reviewing the findings of 24 studies, researchers from the University of Edinburgh concluded that mutations of the filaggrin gene -- which is thought to help maintain an effective skin barrier against the environment -- significantly increase the risk for developing allergic sensitization, atopic eczema, allergic rhinitis and asthma in people with eczema.    From Wordnik.com.  [Medlogs - Recent stories] Reference

F) and filaggrin (G) suggested perturbations in terminal differentiation program of the aged Inv-Cldn6-CΔ196 epidermis.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

M) and filaggrin (N) expression compartments were also expanded, with obvious packing defects evident. doi: 10.1371/journal. pone.0007814.g005.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Figure 5M), loricrin (not shown) and filaggrin (Figure 5N) were also expanded, with an obvious packing defect reminiscent of the observed histological abnormalities of the stratum corneum.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

For double labeling, sections were treated as for single labeling and incubated with a mixture of anti-FLG2 antibody (1: 50 dilution) and a mouse monoclonal anti-filaggrin antibody (1: 200 dilution; Biologo, Kronshagen.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

TCHH, trichohyalin; RPTN, repetin; HRNR, hornerin; FLG, filaggrin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

FLG, filaggrin; FLG2, filaggrin-2; HRNR, hornerin; RPTN, repetin; TCHH, trichohyalin; CRNN, cornulin.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference