A family of small molecules called CFTR inhibitors show promising effects in slowing the progression. From Wordnik.com. [THE MEDICAL NEWS] Reference
VX-809, known as a CFTR corrector, aims to increase CFTR function by increasing the trafficking, or movement, of CFTR to the cell surface. From Wordnik.com. [Vertex Pharmaceuticals Initiates Clinical Trial to Evaluate Combination Regimens of VX-770 and VX-809 Targeting the Defective Protein Responsible for Cystic Fibrosis - Yahoo! Finance] Reference
CFTR, the "cystic fibrosis transmembrane conductance regulator". From Wordnik.com. [The Nobel Prize in Chemistry 2004 - Information for the Public] Reference
CFTR cystic fibrosis transmembrane conductance regulator, treatment of CF. From Wordnik.com. [Archive 2004-12-01] Reference
The CFTR mutation that can cause male infertility isn't among those typically tested. From Wordnik.com. [Linking Male Infertility and Disease Risks] Reference
He tests both partners for CFTR gene mutations and refers the couple for genetic counseling. From Wordnik.com. [A Baby at Last!] Reference
Lung Cystic Fibrosis progressive disease of lungs and pancreas (CFTR gene) image image image image. From Wordnik.com. [Archive 2005-04-01] Reference
You see, I have a not very rare genetic condition-- I carry a gene for at least one abnormal CFTR protein. From Wordnik.com. ["Sicker than a Doorknob"] Reference
By knocking out CFTR in mice, a condition was generated that reproduced many features of the human disease. From Wordnik.com. [The 2007 Nobel Prize in Physiology or Medicine - Advanced Information] Reference
I think it needs mechanical breakup but insurance won't cover formal CF treatments for single-copy CFTR cases. From Wordnik.com. ["Sicker than a Doorknob"] Reference
When this is the case, a urologist should do a more thorough genetic test of the CFTR gene in the man and his partner. From Wordnik.com. [Linking Male Infertility and Disease Risks] Reference
Individuals receive two copies of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, one from each parent. From Wordnik.com. [Molecular Biology] Reference
It turned out to be a cAMP-activated choride channel and was termed cystic fibrosis transmembrane conductance regulator (CFTR). From Wordnik.com. [The 2007 Nobel Prize in Physiology or Medicine - Advanced Information] Reference
One form of infertility is caused by a mutation in the CFTR gene, which helps to regulate the production of mucus and other bodily fluids. From Wordnik.com. [Linking Male Infertility and Disease Risks] Reference
For example, 70% of mutant alleles that cause cystic fibrosis (the phenylalanine deletion) code for a CFTR that works just fine if it is folded correctly in vitro. From Wordnik.com. [Dawkins on the OOL] Reference
Normal CFTR proteins are also essential for the entry of Salmonella typhi into cells,58 suggesting that carriers of mutant CFTR genes might be resistant to typhoid fever. From Wordnik.com. ["Sicker than a Doorknob"] Reference
CFTR mutation, the most common mutation in patients with CF. From Wordnik.com. Reference
We recently identified a third class of CFTR blockers with IC. From Wordnik.com. [Digital50.com Digital 50 Daily Industry News RSS Feed] Reference
The defective gene disables or destroys a protein known as CFTR. From Wordnik.com. [The Times of India] Reference
About 12 million Americans are carriers of an abnormal CFTR gene. From Wordnik.com. [National Institutes of Health (NIH) News Releases] Reference
In fact, in the summer of 1993, CFTR had a 7 share of the market. From Wordnik.com. [680news.com] Reference
Ted Rogers charged his radio managers with developing a plan for the future of CFTR. From Wordnik.com. [680news.com] Reference
CFTR into HAE cells, the researchers inserted the gene into human parainfluenza virus. From Wordnik.com. [PLoS Biology: New Articles] Reference
CFTR to the airway lining (or epithelial) cells to help CF patients in clinical trials. From Wordnik.com. [PLoS Biology: New Articles] Reference
The collaboration between Napo and UCSF identified a variety of potent inhibitors of CFTR activity. From Wordnik.com. [The Earth Times Online Newspaper] Reference
Crofelemer was a partial antagonist of CFTR, with maximum inhibition of 65-90\% depending on activating agonist. From Wordnik.com. [Digital50.com Digital 50 Daily Industry News RSS Feed] Reference
CFTR to human ciliated airway epithelial (HAE) cells that are collected from patients and grown in the laboratory. From Wordnik.com. [PLoS Biology: New Articles] Reference
On June 7, 1993, Rogers Radio shocked the broadcasting world when, without warning CFTR became all news radio, 680News. From Wordnik.com. [680news.com] Reference
By inducing the production of functional CFTR, PTC124 addresses one of the underlying genetic defects responsible for CF. From Wordnik.com. [Medlogs - Recent stories] Reference
CFTR and other membrane protein folding and misfolding, structure-traffic relationship, as well as the role of ubiquitination. From Wordnik.com. [Naturejobs - All Jobs] Reference
The researchers established that piglets lacking CFTR have the abnormal ion channel activity that is a hallmark of CF disease. From Wordnik.com. [EurekAlert! - Breaking News] Reference
CFTR-AM, once a powerhouse contemporary hit radio station with a long legacy of success was feeling the effects of music on the FM band. From Wordnik.com. [680news.com] Reference
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