In patients with very sensitive leukaemic cells, therapy could be reduced without loss of efficacy.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The researchers showed in mice how "normal" stem cells could become leukaemic stem cells and induce cancer.    From Wordnik.com.  [Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph] Reference

Suppressing this protein delayed the onset of cancer, slowed down cancer growth, and reversed leukaemic stem cells to a pre-cancerous stage.    From Wordnik.com.  [Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph] Reference

The genetic mutation that creates these pre-leukaemic cells involves the accidental joining-together of two genes - TEL (ETV6) and AML1 (RUNX1).    From Wordnik.com.  [Cancer Research UK - News & Resources] Reference

If we can take skin cells from them and turn them into healthy blood, the product could outcompete the leukaemic cells, Bhatia told the Guardian.    From Wordnik.com.  [The Guardian World News] Reference

People with MLL have leukaemic stem cells which are part-way along the path to being cancerous white blood cells, although not all of them reach this stage.    From Wordnik.com.  [Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph] Reference

By suppressing a protein in the blood, the team at King's College London transformed leukaemic stem cells back into ordinary ones without cancerous features.    From Wordnik.com.  [Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph] Reference

When beta-catenin was completely inactivated in mice with pre-leukaemic cells, the animals did not develop cancer despite carrying all the necessary MLL mutations.    From Wordnik.com.  [Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph] Reference

CML is a disease in which the body produces cancerous (leukaemic) white blood cells. 95% of patients with CML have an abnormality known as the Philadelphia chromosome.    From Wordnik.com.  [Health News from Medical News Today] Reference

This was discovered in a study of identical twin girls, which revealed that pre-leukaemic cells grow in the bone marrow of individuals with this faulty gene for up to 15 years.    From Wordnik.com.  [Cancer Research UK - News & Resources] Reference

Nilotinib, a second generation TKI, is a potent and selective inhibitor of the Bcr-Abl protein, which is responsible for the proliferation of leukaemic white blood cells in Ph+.    From Wordnik.com.  [Health News from Medical News Today] Reference

Us being able to take skin cells and convert them into healthy blood, specifically adult blood, would provide a great substitute product to hopefully out-compete those leukaemic cells.    From Wordnik.com.  [Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph] Reference

These data may help to clarify the so far unexplained clinical effects of IFNα on leukaemic cells, and raise the possibility for new applications of type I interferons to target cancer stem cells.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The case, involving a Japanese mother aged 28 and her daughter, revealed that both patients 'leukaemic cells carried the identical mutated cancer gene BCR-ABL1 even though the infant had not inherited this gene.    From Wordnik.com.  [Top stories from Times Online] Reference

The main focus of the position is to better understand the identity and impact of the normal cellular origin of preleukaemic and leukaemic stem cells, and how different classes of mutations collaborate towards leukaemic transformation.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

A team at the Institute of Cancer Research (ICR) found that a naturally-occurring molecule called TGF-beta, which is produced in response to infection, caused pre-leukaemic stem cells to multiply rapidly at the expense of normal cells.    From Wordnik.com.  [Cancer Research UK - News & Resources] Reference

"These findings show how detailed analysis of leukaemic cells using complementary techniques can enhance our understanding of the genetic basis of leukaemia," said co-author Cheryl Willman, director and CEO, University of New Mexico Cancer Research and Treatment Center.    From Wordnik.com.  [dailyindia.com News Feed] Reference

The latest study, which appears in the Journal of Clinical Investigation, shows that the molecule TGF-beta can create the conditions required for pre-leukaemic cells to multiply, increasing the chance that some will become further damaged and trigger the onset of full leukaemia.    From Wordnik.com.  [Cancer Research UK - News & Resources] Reference

This chromosome produces a protein called Bcr-Abl, which is responsible for the proliferation of leukaemic white blood cells in Ph+ CML. (.    From Wordnik.com.  [Health News from Medical News Today] Reference

Dr Anthony Ford from ICR revealed: "We had already identified that a genetic mutation occurring in the womb created these pre-leukaemic cells.    From Wordnik.com.  [Cancer Research UK - News & Resources] Reference

Dr Shabih Syed, scientific director at Leukaemia Research, which part-funded the study, commented: "Before this study, there had been only circumstantial evidence to implicate infections in the progression from a child carrying pre-leukaemic cells to actually having leukaemia.    From Wordnik.com.  [Cancer Research UK - News & Resources] Reference