Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.    From Wordnik.com.  [Not all "Lact" Words Are the Same] Reference

The researchers wanted to see if they could find a molecule that inhibited Usp14, thus allowing the proteosome to work effectively.    From Wordnik.com.  [PhysOrg.com - latest science and technology news stories] Reference

We have demonstrated that Nrf2 protein turnover in cells is very fast and most of Nrf2 proteins are rapidly degraded via the ubiquitin-proteosome system.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We and others have demonstrated that Keap1 functions as a substrate adaptor protein for a Cul3/Rbx1 E3 ligase complex to target Nrf2 ubiquitination and subsequent proteosome-mediated degradation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Advancement of therapeutics is unfortunately too frequently driven by serendipity; Takeda/Millennium's own successful drug Velcade (bortezomib), a first-in-class proteosome inhibitor, is one example.    From Wordnik.com.  [The War on Cancer: A Long and Ongoing Struggle (ALNY, CELG, MRK, NVS, PFE)] Reference

To explore the molecular mechanism by which dh404 disrupts the Keap1-mediated suppression of Nrf2, we examined effect of dh404 on the Keap1-mediated Nrf2 ubiquitination and subsequent proteosome-mediated degradation as well as the assembling of Keap1-Cul3-Rbx1 E3 ligase complex for the Nrf2 ubiquitination and degradation in HEK293 cells as previously described.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We found that regulation of apoptosis, proteosome function, ion homeostasis and kinase signalling were modulated and these appeared to us as rather predictable findings (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference