Intact single myocyte shortening from double activating mutations in αTm and cTnI.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Compare the two specimens on the slide for myocyte number, size and cellular contents.    From Wordnik.com.  [Recently Uploaded Slideshows] Reference

Cardiac-myocyte "renewal" findings have implications for myocardial-regeneration research.    From Wordnik.com.  [theHeart.org] Reference

Intact single myocyte shortening and Ca2+ transients from double activating αTm and RCM cTnI mutants.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Introduction of exogenous BIN1 forms membrane invaginations as previously reported in other non-myocyte cell types.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

Second, there is a wealth of previous data on effects of single thin filament CM mutations on cardiac myocyte physiology.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The primary functional effects of these CM mutants, when expressed together at the working myocyte level, are presently unknown.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

There was good preservation of myocyte structure with no myofibrillary disarray, myocyte hypertrophy, vacuolation or attenuation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Rudy-Reil D, Lough J (2004) Avian precardiac endoderm/mesoderm induces cardiac myocyte differentiation in murine embryonic stem cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

BHF funded postdoctoral position: Statins directly affect cardiac myocyte function through cholesterol-dependent and independent mechanisms.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

The delivery results in non-myocyte cells suggest that Cav1. 2 delivery to BIN1 is independent of other myocyte-specific organelles and proteins.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

The researchers also found that blood flow forces HDAC5 to break away from myocyte enhancer factor-2 (MEF2), the molecule it normally attaches to.    From Wordnik.com.  [Emaxhealth] Reference

You will study the direct effects of statins on the cardiac myocyte - through cholesterol-dependent (caveolae) and independent (isoprenoid) pathways.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

Therefore, the concept of stimulating myocyte mitotic divisions has dramatic implications for cardiomyocyte regeneration and hence, cardiovascular disease.    From Wordnik.com.  [ScienceBlogs Channel : Life Science] Reference

The following set of experiments tested the combination of a strong myofilament activator, cTnIR193H, with a moderate activator, TmA63V, on myocyte function.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In this study we ascribe the worsening of myocyte mechanical performance to the combined effects that gain of function mutations in cTnI and Tm have on enhancing Ca.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Thereby, in the absence of other myocyte structures as well as the absence of endogenous Cav1. 2, ectopic expression of BIN1 is sufficient to concentrate surface Cav1. 2.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

Linseman DA, Le SS, Laessig TA, Heidenreich KA (2003) Insulin-like growth factor-I suppresses degradation of the pro-survival transcription factor myocyte enhancer factor 2D.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Westfall MV, Rust EM, Metzger JM (1997) Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

While these data are supportive of the dose-response hypothesis, the molecular underpinnings of this heightened disease severity on myocyte function remain largely unanswered.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Thick filament proteins myosin and MyBP-C also affect myocyte function via established reciprocal interactions between myosin cross-bridge cycling and thin filament activation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

We have however not detected any expression pattern change in gene families that are characteristically specific to non-myocyte cell types such as fibroblasts (data not shown).    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Given the central role of thin filament regulation on myocyte performance and the realization that both thin and thick filament CM mutant proteins directly alter myofilament activation.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

To confirm that membrane delivery of Cav1. 2 to BIN1 can occur in non-myocyte cells, we evaluated surface expression patterns of exogenous Cav1. 2 in HeLa cells expressing exogenous BIN1.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

40X image of one myocyte expressing both eGFP and β-galactosidase.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Figure 4B) demonstrate the 2.5 fold difference in myocyte relaxation between cTnCG159D and cTnIR193H mutant myocytes.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In this assay direct comparisons of myocyte shortening demonstrated that R193H myocytes are slower to relax than A63V mutants at 50, 75, and 90% relaxation times (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In unloaded functional assays representative sarcomere shortening transients illustrate the effects of αTmA63V, cTnIR193H, and A63V+R193H on cardiac myocyte relaxation (.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Such delivery is not myocyte dependent.    From Wordnik.com.  [PLoS Biology: New Articles] Reference

The average yield from rat myocyte isolations is.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

2+ sensitivity and thin filament cooperativity thereby modifying myocyte force development and relaxation performance.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

9\% inhibitions of oligomycin-sensitive F1F0 ATPase activity, respectively. protein kinase C in cardiac myocyte mitochondria, which was enhanced following a.    From Wordnik.com.  [Journal of Biological Chemistry current issue] Reference

(2003) Modeling beta-adrenergic control of cardiac myocyte contractility in silico.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference