Detachment of the retina may occur, often preceded by or accompanied by subretinal hemorrhage.    From Wordnik.com.  [Glaucoma A Symposium Presented at a Meeting of the Chicago Ophthalmological Society, November 17, 1913] Reference

In comparison, subretinal delivery of cells including bone marrow derived cells.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

/5 (AAV2 /5), and delivered via subretinal injection to the normal canine retina.    From Wordnik.com.  [Naturejobs - All Jobs] Reference

A transient increase of MCP-1 protein and mRNA at PI-1 was detected in the retinas following subretinal injection.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Examination of TNF-α expression in mouse retinas following subretinal delivery of compacted DNA nanoparticles or saline.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Coupled with damage to Bruch's membrane, this leads to proliferation of choroidal vessels, which invade the subretinal space.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Immunofluorescence detection of EGFP expression in mouse retinas following subretinal delivery of compacted DNA nanoparticles or saline.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Here we report that subretinal delivery of DNA nanoparticles does not induce inflammatory infiltrates or significant levels of cytokines.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Immunohistochemical examination of MPO expression in mouse retinas following subretinal delivery of compacted DNA nanoparticles or saline.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Immunofluorescence examination of F4/80 expression in mouse retinas following subretinal delivery of compacted DNA nanoparticles or saline.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

If there is a local inflammatory response and PMN infiltration following subretinal delivery of nanoparticles, MPO will be activated and released.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Histological examination of inflammatory cell infiltration in mouse retinas following subretinal delivery of compacted DNA nanoparticles or saline.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Wang S, Lund RD (2005) Time course of deterioration of rod and cone function in RCS rat and the effects of subretinal cell grafting: a light - and dark-adaptation study.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In this study we show that the CK30PEG-compacted DNA nanoparticles containing a CMV-EGFP expression vector are non-toxic and well-tolerated in the murine eye after subretinal injection.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

In Europe, a group of scientists has implanted a subretinal prosthesis in 11 people, said Dr. Eberhart Zrenner, director of the Center for Ophthalmology at the University of Tüebingen in Germany.    From Wordnik.com.  [NYT > Technology] Reference

The standard transvitreal subretinal injection procedure will create a localized detached region near the injection site in the central-temporal region for the right eye and the central-nasal region for the left eye.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

Our most recent studies have demonstrated that these nanoparticles can be used to provide partial structural and functional rescue of a retinitis pigmentosa disease phenotype after subretinal delivery to the diseased mouse eye.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

The Boston project team has used its subretinal prototype in animals but not in humans, although it expects to have a device for human patients to present to the Food and Dr.g Administration in about two years, Dr. Wyatt said.    From Wordnik.com.  [NYT > Technology] Reference

An advantage of delivering donor cells via subretinal injection method is that the therapeutic material is placed directly in the space where the defective RPE cells or degenerating photoreceptors are targeted, and in this fashion both photoreceptors and visual function can be partially preserved.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

One patient was so thrilled with the results, the company added, that he refused to have the implants removed after the study's one - or three-month testing period, and he reports continued success four years later. subretinal implants, it described in a statement, place the chip in the macular region, beneath the retina.    From Wordnik.com.  [CNET News.com]

Our current observations on the lack of overt nanoparticle-associated toxicity are in keeping with our previous work which demonstrated that saline and nanoparticle injected eyes had no differences in maximum ERG amplitude (scotopic or photopic) and that after recovery from the subretinal injection procedure the ERG recordings were not different from uninjected control eyes pZEOGFP5. 1 plasmid encoding the EGFP cDNA transcriptionally-controlled by the CMV immediate-early promoter and enhancer.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference

6A, markedly elevated levels of MCP-1 were detected in the Examination of MCP-1 expression in mouse retinas following subretinal delivery of compacted DNA nanoparticles or saline.    From Wordnik.com.  [PLoS ONE Alerts: New Articles] Reference