This agent was not described as metabolite in report, but it should be noted that diazepam breaks down into oxazepam. From Wordnik.com. [Anna Nicole Smith Autopsy: Abused Growth Hormone, Killed by Sleeping Aid.] Reference
This is in contrast to the pharmacokinetics of Clopidogrel's active metabolite, which is affected by genetic variations in CYP2C19. From Wordnik.com. [SeekingAlpha.com: Home Page] Reference
A metabolite contributing to morbidity and mortality. From Wordnik.com. [Loads] Reference
This was mirrored by transcriptional and metabolite perturbations. From Wordnik.com. [A Cause of Schizophrenia?] Reference
Diazepam is metabolized to nordiazepam which is an active metabolite. From Wordnik.com. [Anna Nicole Smith Autopsy: Abused Growth Hormone, Killed by Sleeping Aid.] Reference
In some cases, the metabolite is more toxic than the excreted conjugate. From Wordnik.com. [Excretion of toxicants] Reference
Now, I must say that some of the metabolite actually came about after she died. From Wordnik.com. [CNN Transcript Aug 18, 2005] Reference
The “invention” is the relationship between metabolite and toxicity/efficacy. From Wordnik.com. [The Volokh Conspiracy » Mayo Collaborative Servs. v. Prometheus Laboratories, Inc.] Reference
Rats more efficiently convert BPA into a non-estrogenic metabolite than do humans. From Wordnik.com. [Hippie swag bottles pose significant health risk | Jewschool] Reference
The responsible elements appear to be genistein and equol, a metabolite of daidzen. From Wordnik.com. [Craig Cooper: Soy: When It's Good, When It's Bad, And How To Tell] Reference
New evidence suggests that a nicotine metabolite improves memory and combats Alzheimer's. From Wordnik.com. [Boing Boing: November 9, 2003 - November 15, 2003 Archives] Reference
Finasteride Propecia reduces the conversion of testosterone to its potent metabolite DHT. From Wordnik.com. [Glenn D. Braunstein, M.D.: Hair Today, Gone Tomorrow] Reference
For some pharmaceuticals, it is a metabolite that is therapeutic and not the absorbed drug. From Wordnik.com. [Biotransformation] Reference
Why do we have receptors for nitric oxide, an air pollutant and a metabolite of nitroglycerin?. From Wordnik.com. [Louis J. Ignarro - Autobiography] Reference
Promotes the active metabolite of vitamin D in the kidneys, aiding in the absorption of calcium. From Wordnik.com. [Anatomy 101: The Parathyroid Gland And How It Affects Our Health.] Reference
Usually the Phase II metabolite is quite hydrophilic and can be readily eliminated from the body. From Wordnik.com. [Biotransformation] Reference
A good example is phenol that can be directly conjugated into a metabolite that can then be excreted. From Wordnik.com. [Biotransformation] Reference
These riboswitches fold into intricate structures that can distinguish one metabolite from another (5). From Wordnik.com. [Exploring the New RNA World] Reference
I will try to orient as much as possible around MS-based metabolomics, and metabolite identity in particular. From Wordnik.com. [CompLife2007, Utrecht/NL; Taverna, EBI/Hinxton/UK] Reference
Diazepam (Valium), a benzodiazepine used to treat anxiety and alcohol withdrawal.a. Nordiazepam (metabolite). From Wordnik.com. [Anna Nicole Smith Autopsy: Abused Growth Hormone, Killed by Sleeping Aid.] Reference
In addition, mitotic rate, drug transport and metabolite pool sizes can be responsible for selective toxicity. From Wordnik.com. [Nobel Lecture The Purine Path To Chemotherapy] Reference
The extremely fit – 25 Boston Marathon runners – had ten-fold increases in that metabolite after the race. From Wordnik.com. [10 Minutes Of Exercise, Hour-Long Effects] Reference
So if you're testing for a metabolite, might one individual make more of the metabolite than another individual?. From Wordnik.com. [CNN Transcript Aug 7, 2008] Reference
The result is a conjugated metabolite that is more water-soluble than the original xenobiotic or Phase I metabolite. From Wordnik.com. [Biotransformation] Reference
The product consists of a mix of humic acids, algae extracts, a non-hormonal reductant plant metabolite, and vitamins. From Wordnik.com. [1. Soil constraints on sustainable plant production in the tropics.] Reference
In addition, the glutathione in the liver may also be depleted so that the toxic metabolite is not detoxified and eliminated. From Wordnik.com. [Biotransformation] Reference
This is an abnormal metabolite, since it does not seem that adrenalin in the body normally passes through the adrenochrome stage. From Wordnik.com. [The Human Brain]
That is, if there is too much metabolite there will be toxicity and if there is not enough there will not be therapeutic efficacy. From Wordnik.com. [The Volokh Conspiracy » Mayo Collaborative Servs. v. Prometheus Laboratories, Inc.] Reference
Some researchers have speculated that NAD, a cofactor of Sir2 and a common metabolite in the cell, acts as a regulatory mechanism. From Wordnik.com. [Boing Boing: May 18, 2003 - May 24, 2003 Archives] Reference
In other cases, the xenobiotic may enter a different biotransformation pathway that may result in the production of a toxic metabolite. From Wordnik.com. [Biotransformation] Reference
DDT and its metabolite DDE alter hormones, that affect calcium metabolism and can impact reproduction and development of exposed animals. From Wordnik.com. [DDT] Reference
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